Gasdermin d. .

Gasdermin d. [6] It belongs to the gasdermin family which is Overview Belonging to the GSDM family, gasdermin D (GSDMD) actively mediates the pathogenesis of inflammatory diseases by Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial damage, but its underlying mechanism Gasdermin D (GSDMD) is the first identified executor of pyroptosis within the GSDM family. Gasdermin D (GSDMD, from combination of gastro and dermato, referencing the locations where its family of proteins were originally found to be primarily expressed [5]) is a protein that in humans is encoded by the GSDMD gene on chromosome 8. Recent discoveries have revealed GSDMD is the executioner of pyroptosis; the full-length protein is inactive before cleavage and plays a crucial role in host defense against pathogen In this review, we provide an overview of the current understanding of the major activation mechanisms and effector pathways of GSDMD. . It is activated by cleavage from caspase-1/4/5/11 under various stress stimuli, GSDMD forms membrane pores that can promote cytolysis and the release of interleukin-1 family cytokines into the extracellular space. It Gasdermin D (GSDMD) is a critical pyroptosis mediator, consisting of one N-terminal pore-forming domain and one C-terminal auto-inhibitory domain. This review summarizes the structure, activation, and function of gasdermin D (GSDMD), a key protein in pyroptosis and inflammation. qz 4ek sgii9 fmgla vx ciwv onfl kby 8s2hj tpsm9ww